|
Symbol Name ID |
Myh9
myosin, heavy polypeptide 9, non-muscle MGI:107717 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA level |
Increased circulating IgE level |
Abnormal bleeding |
Epistaxis |
Spontaneous, recurrent epistaxis |
Joint hemorrhage |
Menorrhagia |
Persistent bleeding after trauma |
Prolonged bleeding time |
Bruising susceptibility |
Petechiae |
Abnormal megakaryocyte morphology |
Increased megakaryocyte colony forming unit count |
Megakaryocyte dysplasia |
Anemia of inadequate production |
Poikilocytosis |
Acanthocytosis |
Leukocytosis |
Neutrophil inclusion bodies |
Leukocyte inclusion bodies |
Abnormal thrombosis |
Impaired ADP-induced platelet aggregation |
Impaired epinephrine-induced platelet aggregation |
Thrombocytopenia |
Congenital thrombocytopenia |
Intermittent thrombocytopenia |
Macrothrombocytopenia |
Abnormal platelet shape |
Abnormal platelet volume |
Decreased mean platelet volume |
Increased mean platelet volume |
Giant platelets |
| Disease(s) Associated with MYH9 | ||||||||||||||||||||||||||||||||
| MYH-9 related disease | ||||||||||||||||||||||||||||||||
| thrombocytopenia |
| Mouse Phenotypes | hematopoietic system phenotype |
abnormal megakaryocyte differentiation |
abnormal leukocyte migration |
abnormal leukocyte adhesion |
abnormal thrombopoiesis |
abnormal megakaryocyte morphology |
increased megakaryocyte cell number |
abnormal neutrophil morphology |
abnormal platelet morphology |
thrombocytopenia |
abnormal platelet shape |
decreased CD8-positive, alpha-beta T cell number |
abnormal T cell physiology |
abnormal CD8-positive, alpha-beta T cell physiology |
abnormal platelet physiology |
|
| Availability | Mouse Genotype | |||||||||||||||
| Myh9tm1.1(MYH9*)Mjk/Myh9tm1.1(MYH9*)Mjk | ||||||||||||||||
| Myh9tm1.2Gac/Myh9tm1.2Gac | * | |||||||||||||||
| Myh9tm7.1Rsad/Myh9tm7.1Rsad | ||||||||||||||||
| Myh9Gt(Betageo-btk)1Dash/Myh9+ | * | |||||||||||||||
| Myh9tm1.1(MYH9*)Mjk/Myh9+ | ||||||||||||||||
| Myh9tm1.1Dash/Myh9+ | ||||||||||||||||
| Myh9tm6.1(EGFP/MYH9*)Rsad/Myh9+ | ||||||||||||||||
| Myh9tm7.1Rsad/Myh9+ | ||||||||||||||||
| Myh9tm1.1Gac/Myh9tm1.1Gac Tg(Pf4-icre)Q3Rsko/0 (conditional) |
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| Myh9tm5Rsad/Myh9tm5Rsad (conditional) | ||||||||||||||||
| Myh9tm5Rsad/Myh9tm5Rsad Tg(Lck-cre)#Nik/0 (conditional) |
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| Myh9tm1.1Gac/Myh9+ Tg(Pf4-icre)Q3Rsko/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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